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KMID : 0903520080510040309
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 4 p.309 ~ p.315
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Anti-cancer Activity of Flavonoids from Aceriphyllum rossii
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Ahn Eun-Mi
Han Jae-Taek
Kwon Byoung-Mog
Kim Sung-Hoon
Baek Nam-In
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Abstract
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The methanol extract from the aerial parts of Aceriphyllum rossii was fractionated into ethyl acetate, n-BuOH and H2O layers through solvent fractionation. Repeated silica gel column chromatography of EtOAc and n-BuOH layers afforded five flavonol glycosides. They were identified as astragalin (1), kaempferol 3-O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (2), rutin (3), kaempferol 3-O-α-L-rhamnopyranosyl (1→4)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (4), and quercetin 3-O-α-L-rhamnopyranosyl (1→4)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (5) on the basis of spectroscopic data. All of them showed an inhibition in farnesyl protein tranferase (FPTase) activity, and rutin (3) inhibited the growth of rat H-ras cell and the cell migration of human umbilical vein endothelial cells (HUVECs).
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KEYWORD
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Aceriphyllum rossii, anti-cancer, cell migration, flavonol glycoside, FPTase, H-ras
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